Peer-reviewed veterinary case report
Estimating lung blood vessel resistance in dogs with mitral valve
By Suzuki, Ryohei et al.·Published in Frontiers in veterinary science·2021·Faculty of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Pulmonary Vascular Resistance Estimated by Echocardiography in Dogs With Myxomatous Mitral Valve Disease and Pulmonary Hypertension Probability.
- Species:
- dog
Plain-English summary
A group of dogs with myxomatous mitral valve disease (MMVD) and signs of heart failure underwent echocardiograms to assess their risk of pulmonary hypertension (PH), a serious condition affecting the lungs. The tests measured heart function and blood flow, revealing that dogs with higher PH risk had larger right ventricles and lower blood flow velocities. These findings suggest that echocardiography can help veterinarians determine the severity of heart issues and the likelihood of complications in dogs with MMVD. Early detection and monitoring can lead to better management of their condition.
People also search for: dog heart failure symptoms · myxomatous mitral valve disease treatment · pulmonary hypertension in dogs
Abstract
Post-capillary pulmonary hypertension (PH) is a life-threatening complication in dogs with myxomatous mitral valve disease (MMVD). An increase in pulmonary vascular resistance (PVR) is associated with post-capillary PH progression. In humans, PVR estimated by echocardiography (PVRecho) enables the non-invasive assessment of PVR in patients with PH. This study aimed to evaluate the clinical utility of PVRecho in dogs with MMVD, PH probability, and right-sided congestive heart failure (R-CHF). Dogs with MMVD and detectable tricuspid valve regurgitation were included in the study. Dogs were classified into three PH probability groups (low/intermediate/high) and according to the presence or absence of R-CHF. All dogs underwent echocardiographic measurements for right ventricular (RV) morphology and function. PVRecho was calculated by two methods using tricuspid valve regurgitation velocity and velocity-time integral of the pulmonary artery flow (PVRecho and PVRecho2). RV size indicators were significantly higher with a higher probability of PH. RV strain and velocity-time integral of the pulmonary artery flow in the high probability group were significantly lower than those in the other groups. Tricuspid valve regurgitation velocity, PVRecho, and PVRecho2 were significantly higher with an increase in PH probability. Logistic regression analysis revealed a significant association between the presence of R-CHF and increased PVRecho2 and end-diastolic RV internal dimension normalized by body weight. PVRecho and PVRecho2 showed significant differences among the PH probability groups. These non-invasive variables may be useful for the diagnosis and stratification of PH and the determination of the presence of R-CHF in dogs with MMVD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34765671/