Peer-reviewed veterinary case report
Dog with pyoderma gangrenosum ulcers improves after prednisolone
By Nagata, Noriyuki et al.·Published in The Journal of veterinary medical science·2016·Yuki Animal Hospital, Japan·View original on PubMed →
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Original publication title: Pyoderma gangrenosum after trauma in a dog.
- Species:
- dog
Plain-English summary
A 12-year-old male Miniature Pinscher was brought in with painful sores on his body that were getting worse over time. The vet suspected a condition called pyoderma gangrenosum, which can occur after trauma, and started the dog on a medication called prednisolone. After starting treatment, the dog's condition improved significantly, with the sores healing and becoming less severe. This case highlights how effective prednisolone can be for treating this serious skin issue in dogs.
People also search for: dog skin sores treatment · Miniature Pinscher pyoderma gangrenosum · prednisolone for dog skin problems
Abstract
A 12-year-old male entire Miniature Pinscher presented with excoriations at various body sites, progressively forming ulcers and enlarging until arrested by treatment. Based on the clinical presentation and histopathological analyses, sterile neutrophilic dermatosis was suspected. Therefore, the dog was started on prednisolone. Marked improvement was achieved with prednisolone treatment, suggesting a diagnosis of pyoderma gangrenosum (PG). Transcription levels of cytokine mRNA in lesional skin before and after treatment from this dog were quantified by real-time RT-PCR. Transcription levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-8 and IL-17A were higher in lesional skin before treatment than after treatment. Levels of various cytokines could be increased in lesional skin of dogs with PG as well as in human patients with PG.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27108868/