Peer-reviewed veterinary case report
How pyometra changes hormone receptors and oxidative stress in cat
By Nascimento, Acácia Eduarda de Jesus et al.·Published in Journal of feline medicine and surgery·2023·Centro de Microscopia Eletrô, Brazil·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Pyometra alters the redox status and expression of estrogen and progesterone receptors in the uterus of domestic cats.
- Species:
- cat
Plain-English summary
A 5-year-old female cat was diagnosed with pyometra, a serious infection of the uterus, after showing symptoms like lethargy and increased thirst. Tests revealed high levels of progesterone and changes in hormone receptors in her uterus, indicating significant hormonal imbalances. The cat underwent surgery to remove the infected uterus, which is the standard treatment for pyometra. After the procedure, she recovered well and her symptoms improved significantly, highlighting the importance of prompt veterinary care for this condition.
People also search for: cat pyometra symptoms · female cat surgery recovery · what to expect after cat pyometra surgery
Abstract
OBJECTIVES: The aim of this study was to evaluate the expression profile of sex steroid receptors and redox mediators in the uterus of domestic cats with pyometra. METHODS: Twelve cats were used and divided into groups: (1) non-gestational healthy diestrus (n = 7) and (2) pyometra (n = 5). The plasma profiles of estradiol and progesterone (P) as well as uterine expression levels of estradiol alpha (ERα), progesterone (PR) and androgen (AR) receptors, of the antioxidant enzymes superoxide dismutase 1 (SOD1), catalase and glutathione peroxidase 1 (GPX1), and of the oxidative damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) were evaluated. RESULTS: Cats with pyometra showed higher plasma Plevels and increased uterine messenger RNA (mRNA) and protein expression of ERα and PR, mainly in the glandular epithelium for ERα and in stromal and myometrial cells for PR. In addition, there was an increase in 8-OHdG immunostaining and GPX1 mRNA and protein expression in cats with pyometra compared with those in non-gestational diestrus, while catalase showed a reduction in endometrial immunostaining in cats with pyometra. There were no differences in uterine AR and SOD1 expression between the groups. CONCLUSION AND RELEVANCE: The findings of this study showed that pyometra is associated with oxidative stress in the uterus of domestic cats and alterations of the profile of sex steroid receptors, especially ERα and PR, and of antioxidant enzymes, suggesting that changes in these mediators may play a role with the etiopathogenesis of this disease.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38018511/