Peer-reviewed veterinary case report
Nerve damage and hind leg issues in dogs from high pyridoxine
By Chung, Jin-Young et al.·Published in Journal of veterinary science·2008·Department of Veterinary Internal Medicine, South Korea·View original on PubMed →
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Original publication title: Pyridoxine induced neuropathy by subcutaneous administration in dogs.
- Species:
- dog
Plain-English summary
A group of dogs received high doses of pyridoxine (a form of vitamin B6) through injections over a week, which led to weight loss and problems with their back legs. The dogs showed a loss of sensation in their hindquarters, and tests revealed nerve damage in specific areas. Fortunately, the treatment did not cause any serious overall health issues. This research suggests that while pyridoxine can induce nerve problems in dogs, it can be done safely in a controlled setting.
People also search for: dog weight loss hind leg problems · pyridoxine side effects in dogs · dog nerve damage treatment
Abstract
To construct a sensory neuropathy model, excess pyridoxine (150 mg/kg s.i.d.) was injected subcutaneously in dogs over a period of 7 days. During the administrations period, the dogs experienced body weight reduction and proprioceptive loss involving the hindquarters. After pyridoxine administration was completed, electrophysiological recordings showed that the M wave remained at a normal state, but the H-reflex of the treated dogs disappeared at 7 days. The dorsal funiculus of L(4) was disrupted irregularly in the axons and myelin with vacuolation. The dorsal root ganglia of L(4), and sciatic and tibial nerves showed degenerative changes and vacuolation. However, the lateral and ventral funiculi of L(4) showed a normal histopathologic pattern. Although this subcutaneous administration method did not cause systemic toxicity and effectively induced sensory neuropathy, this study confirmed the possibility of producing a pyridoxine-induced sensory neuropathy model in dogs with short-term administration.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18487933/