Peer-reviewed veterinary case report
Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
- Journal:
- Bioorganic & medicinal chemistry letters
- Year:
- 2006
- Authors:
- Adams, David R et al.
- Affiliation:
- Vernalis plc · United Kingdom
- Species:
- rodent
Abstract
A series of 1-(1-pyrrolo(iso)quinolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for the compounds at 5-HT(2) receptor subtypes are reported. The analogue which showed the highest 5-HT(2C) binding affinity (27, 1.6nM) was found to be successful in reducing food intake in rats.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16257207/