Qinglongyi nanoparticles alleviate neuroinflammation and promote neuronal survival by inhibiting neuronal ferroptosis in intracerebral hemorrhage.

Abstract

Intracerebral hemorrhage (ICH) is a severe cerebrovascular disorder with extremely high mortality and disability rates. Currently, effective medications for ICH are scarce, and the development of novel and efficacious drugs for its management is urgently needed. Neuronal ferroptosis and neuroinflammation are important pathophysiological processes occurring during the progression of ICH. Nevertheless, the potential relationship between neuronal ferroptosis and neuroinflammation during ICH remains to be clarified. Therefore, elucidating this relationship and further developing therapeutic drugs may provide feasible treatments for ICH. Here, we confirmed that ICH can induce neuronal ferroptosis, which can result in proinflammatory microglial polarization and ultimately trigger neuroinflammatory progression after ICH. Qinglongyi nanoparticle (QLY NP) treatment can suppress neuronal ferroptosis, thereby inhibiting proinflammatory microglial polarization, reducing the hematoma volume in mice and ultimately facilitating neuronal survival and alleviating neuroinflammation in the context of ICH. Concurrently, QLY NP treatment resulted in minimal toxicity in mice. Overall, we showed that the QLY NPs could inhibit neuronal ferroptosis, thereby alleviating neuroinflammation and ultimately leading to promising therapeutic outcomes in an ICH model. Hence, with further research, QLY NPs may be an efficacious treatment for ICH.