Peer-reviewed veterinary case report
Chemokine gene changes in duodenal tissue of dogs with inflammatory
By Maeda, Shingo et al.·Published in Veterinary immunology and immunopathology·2011·Department of Veterinary Internal Medicine, Japan·View original on PubMed →
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Original publication title: Quantification of chemokine and chemokine receptor gene expression in duodenal mucosa of dogs with inflammatory bowel disease.
- Species:
- dog
Plain-English summary
A group of dogs with inflammatory bowel disease (IBD) showed higher levels of certain immune-related proteins in their intestines compared to healthy dogs. These proteins, called chemokines, are involved in the immune response and were found to be more active in dogs with more severe symptoms. However, the study did not find a link between these protein levels and the actual damage seen in the intestines. This suggests that these chemokines might be important in understanding and treating IBD in dogs.
People also search for: dog inflammatory bowel disease symptoms · IBD treatment for dogs · dog intestinal health issues
Abstract
Although chemokines and their receptors play an integral role in the regulation of the immune response, there is very little information about their involvement in canine inflammatory bowel disease (IBD). The objective of this study was to evaluate the mRNA expression of 9 selected chemokines and 6 chemokine receptors by real-time reverse transcription PCR in the duodenal mucosa from 21 dogs with IBD and 25 control dogs. The transcription levels of monocyte chemotactic protein-1 (MCP-1)/CCL2, macrophage inflammatory protein-3 alpha (MIP-3α)/CCL20, thymus-expressed chemokine (TECK)/CCL25, mucosae-associated epithelial chemokine (MEC)/CCL28 and IL-8/CXCL8 mRNA in IBD dogs were significantly higher than the corresponding levels in control dogs, but there was no significant difference in the mRNA levels of the chemokine receptors between the 2 groups. In addition, the CCL2 and CXCL8 mRNA levels were significantly higher in the high clinical severity score group than in the low clinical severity score group. However, there was no correlation between chemokine or chemokine receptor mRNA expressions and histopathological severity score. The present results suggest that several chemokines may play important roles in the pathogenesis of canine IBD.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21996024/