Peer-reviewed veterinary case report
How maternal antibodies pass to puppies in colostrum and cord blood
By Teh, Serena S et al.·Published in Frontiers in immunology·2025·Baker Institute for Animal Health, United States·View original on PubMed →
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Original publication title: Quantifying maternal antibody transfer to colostrum and cord blood reveals virus-specific selectivity in dogs.
- Species:
- dog
Plain-English summary
A study looked at how well mother dogs pass on protective antibodies to their puppies through colostrum (the first milk) and the placenta. The researchers found that while only a small amount of antibodies crossed the placenta, the colostrum was rich in antibodies specifically targeting dangerous viruses like parvovirus and distemper. This means that puppies get a strong boost to their immune system from their mother's first milk. The study highlights the importance of ensuring that mother dogs have high levels of these protective antibodies before giving birth to help keep their puppies healthy.
People also search for: why is my puppy getting sick · dog colostrum benefits · maternal antibodies in puppies
Abstract
BACKGROUND: Neonatal infections are a leading cause of mortality in dogs, with up to 30% of puppies dying within the first 3 weeks of life. During this critical period of immune development, protection is highly dependent on maternal antibodies (MatAbs) transferred across the placenta and via colostrum. Despite the critical importance of this transfer, limited information is available regarding the biological or clinical factors that determine its magnitude, whether specific antibodies are preferentially transferred, or how these processes vary across a broad population of dogs. METHODS: To quantify and explore the determinants of MatAb transfer in dogs, we analyzed matched maternal serum, cord blood, and colostrum samples collected from 44 client-owned dams undergoing cesarean section at a university veterinary hospital. Total immunoglobulin G (IgG) and virus-specific antibodies against canine parvovirus (CPV) and canine distemper virus (CDV) were analyzed. We also evaluated the influence of maternal factors, including age, breed, body weight, parity, and litter size, on MatAb transfer efficiency. RESULTS: Across this diverse population, we observed limited transplacental transfer of MatAbs (4.5%-6% of the maternal titer), consistent with previous studies and as expected given the endotheliochorial placenta of dogs. In contrast, virus-specific IgG was highly enriched in colostrum, with 10.7-fold (CPV) and 8.1-fold (CDV) increases relative to serum. Transfer efficiency was significantly greater for virus-specific antibodies than for total IgG (3.2-fold), suggesting selective enrichment of antiviral antibodies during colostrogenesis. Maternal serum antibody titer emerged as the primary factor influencing antibody transfer efficiency. CONCLUSIONS: These findings provide the most comprehensive quantification to date of MatAb transfer routes in dogs, revealing preferential transfer of virus-specific IgG to colostrum and highlighting the crucial role of colostrum intake in neonatal immunity. This work establishes a foundation for identifying antibody characteristics that influence MatAb transfer efficiency and reinforces the importance of ensuring that dams have adequate titers of virus-specific IgG prior to breeding.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41613107/