Peer-reviewed veterinary case report
Genes linked to hip dysplasia in UK Labrador Retrievers
By Sánchez-Molano, Enrique et al.·Published in BMC genomics·2014·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers.
- Species:
- dog
Plain-English summary
A study focused on UK Labrador Retrievers found specific genetic markers linked to hip dysplasia, a condition that causes hip joint malformation and can lead to lameness and arthritis. By identifying these genetic regions, researchers hope to improve breeding practices to reduce the occurrence of hip dysplasia in future generations. The findings suggest that using a broader genomic selection approach could be more effective than current methods in combating this common issue in Labradors.
People also search for: Labrador hip dysplasia symptoms · hip dysplasia treatment in dogs · genetic testing for Labrador hip problems
Abstract
BACKGROUND: Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC). RESULTS: Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia. CONCLUSION: Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25270232/