Peer-reviewed veterinary case report
Questioning the value of (99m)Tc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer.
- Journal:
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
- Year:
- 2011
- Authors:
- Beekman, Chantal A C et al.
- Affiliation:
- Netherland Cancer Institute - Antoni van Leeuwenhoek Hospital · Netherlands
Abstract
Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of (99m)Tc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in (99m)Tc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, (99m)Tc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/21227707/