Peer-reviewed veterinary case report
Radioimmunoassay for parathyroid hormone in equids.
- Journal:
- American journal of veterinary research
- Year:
- 1987
- Authors:
- Roussel, A J et al.
- Species:
- horse
Plain-English summary
Researchers tested a method to measure parathyroid hormone (PTH) levels in horses, looking at both healthy horses and those with high calcium and low phosphorus levels. They found that the method worked well, showing expected changes in PTH levels when they adjusted calcium in healthy horses. They established normal PTH levels for different groups of horses, with healthy mares and geldings showing levels below 0.27 to 0.92 ng/ml, while young colts fed grain had levels between 0.61 and 1.25 ng/ml. In two horses with high calcium levels, one pony had a condition called primary hyperparathyroidism (where the parathyroid glands are overactive) and the other horse had pseudohyperparathyroidism (a condition that mimics the effects of hyperparathyroidism), and both had higher than normal PTH levels. This suggests that the test can help identify issues related to parathyroid hormone in horses.
Abstract
Radioimmunoassay for parathyroid hormone (PTH) in equids was performed on blood samples from healthy equids and equids with hypercalcemia and hypophosphatemia. The assay was validated for equine carboxy-terminal PTH. Manipulation of serum ionized Ca in healthy equids by infusing Na2 EDTA and CaCl2 produced an expected increase and decrease, respectively, in measurable immunoreactive PTH. Intra-assay and interassay coefficients of variation were 2.6% and 11.7%, respectively. The range of PTH valves for healthy mature horse mares and geldings maintained on pasture was less than 0.27 ng/ml to 0.92 ng/ml and for horse colts fed grain was 0.61 to 1.25 ng/ml. Serum PTH values were measured on 2 equine patients with hypercalcemia, 1 pony with primary hyperparathyroidism and 1 horse with pseudohyperparathyroidism. Both patients had increased serum PTH values.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/3592356/