Peer-reviewed veterinary case report
Dog with thymoma developed tumor lysis syndrome after radiotherapy
By Wada, Yusuke et al.·Published in The Journal of veterinary medical science·2021·College of Life, Japan·View original on PubMed →
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Original publication title: Radiotherapy-induced tumor lysis syndrome in a dog with thymoma.
- Species:
- dog
Plain-English summary
A 13-year-old female mixed-breed dog developed lethargy and stopped eating the day after receiving radiotherapy for a large tumor in her chest. Blood tests showed serious imbalances, including high levels of certain waste products and low calcium, along with decreased urine output. The dog was treated with fluids and diuretics, which helped her recover temporarily. Unfortunately, she passed away suddenly 11 days later, and a necropsy revealed kidney damage likely caused by tumor lysis syndrome (TLS) related to the treatment. This case highlights the importance of monitoring for TLS in dogs with thymoma undergoing radiotherapy.
People also search for: dog lethargy after radiotherapy · thymoma in dogs · tumor lysis syndrome treatment in dogs
Abstract
A 13-year-old, female, mixed-breed dog with a huge cranial mediastinal mass underwent radiotherapy (RT). On the following day, the dog presented with lethargy and anorexia. Hematological examination revealed elevated levels of blood urea nitrogen, creatinine, inorganic phosphorus, potassium, lactate dehydrogenase, creatine phosphokinase and aspartate aminotransferase, decreased calcium level, and metabolic acidosis. Urine output markedly decreased. The patient recovered with fluid therapy and diuretic therapy; however, died suddenly from an unknown cause 11 days after RT completion. Histopathological examination after necropsy showed thymoma in the cranial mediastinum and extensive tubular necrosis of both kidneys which may be due to RT-induced tumor lysis syndrome (TLS). This report suggests that the risk of TLS should be evaluated in dogs with thymoma who undergo RT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34148912/