Peer-reviewed veterinary case report
Ranitidine Can Potentiate The Prokinetic Effect Of Itopride At Low Doses- An In Vitro Study.
- Journal:
- Journal of Ayub Medical College, Abbottabad : JAMC
- Year:
- 2017
- Authors:
- Butt, Aroosa Ishtiaq et al.
- Affiliation:
- Department of Pharmacology
- Species:
- rabbit
Plain-English summary
This study looked at how two medications, ranitidine (an acid blocker that can also help move food through the stomach) and itopride (a drug that helps with stomach movement), work together in rabbits. Researchers tested different amounts of these drugs on pieces of rabbit intestines and found that at low doses, ranitidine boosted the effects of itopride, making the intestines contract more effectively. However, when they used higher doses of ranitidine, this helpful effect started to decrease. Overall, the combination of ranitidine and itopride at low doses showed a significant improvement in stomach movement in the lab setting.
Abstract
BACKGROUND: Gastroparesis and GERD occur concomitantly in 40 percent of the cases. Prokinetic drugs and acid blockers are employed as the main treatment modality. Ranitidine is an acid blocker with additional prokinetic activity and Itopride is a known prokinetic drug. This study was designed to observe the synergistic potentiating prokinetic effect of Ranitidine on itopride on isolated duodenum of rabbits. METHODS: Ranitidine (10-5-10-3) and itopride (10-6-10-5) were added in increasing concentrations to isolated duodenum of rabbits and contractions were recorded on PowerLab Data acquisition unit AHK/214. Cumulative dose response curves were constructed. The potentiating prokinetic effect of Ranitidine on itopride was seen by using a fixed dose of ranitidine and cumulatively enhancing doses of itopride on iWorx. RESULTS: Ranitidine and itopride produced a dose dependent reversible contraction of the isolated tissue of rabbits with ranitidine showing a max response of 0.124mV and itopride showing a maximum response of 0.131mV. Ranitidine was able to potentiate the prokinetic effect of itopride at low doses but at high dose the effect began to wane off. CONCLUSIONS: Ranitidine and itopride produce a statistically significant synergistic potentiating prokinetic effect at low doses in vitro.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/29330976/