Peer-reviewed veterinary case report
Fast test finds feline chaphamaparvovirus in cats from southwestern
By Chen, Wei et al.·Published in Journal of feline medicine and surgery·2026·Key Laboratory of Animal Medicine of Sichuan Education Department, China·View original on PubMed →
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Original publication title: Rapid detection and genomic characterisation of feline chaphamaparvovirus in southwestern China.
- Species:
- cat
Plain-English summary
A group of cats in southwestern China with diarrhea was tested for a virus called feline chaphamaparvovirus (FeChPV). Researchers developed a sensitive test that found the virus in about 25% of the cats. They also discovered that some of the local virus strains were closely related to those found globally, showing unique genetic traits. This study helps improve detection methods for FeChPV and could lead to better understanding of how the virus affects cats. If your cat has diarrhea, it might be worth discussing this virus with your veterinarian.
Abstract
ObjectivesThis study aimed to develop a sensitive detection method and investigate feline chaphamaparvovirus (FeChPV) in cats from southwestern China.MethodsA SYBR Green I-based qPCR assay targeting the VP1 gene was established and validated. It was then applied to 87 feline diarrhoeic faecal samples (2021-2023). Near-full-length genomes of positive samples were sequenced for phylogenetic, structural and selection analysis.ResultsThe qPCR assay showed high sensitivity (50.9 copies/μl) and reproducibility (coefficient of variation <4.0%). FeChPv was detected in 22/87 (25.3%) cats with diarrhoea. Four strains shared 97.6-99.5% identity with global isolates and formed a distinct clade within Asian lineages. A consistent valine-to-isoleucine mutation at VP1-340 was identified under positive selection, which can induce conformational changes.Conclusions and relevanceWe provide a reliable tool for the detection of FeChPV and reveal unique evolutionary features of local strains, supporting further research into its pathogenesis and spread.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/41328789/