Peer-reviewed veterinary case report
Rapid cooling with heart-lung support helps dogs after long cardiac
By Tanimoto, Hironari et al.·Published in Resuscitation·2007·Department of Anesthesiology, Japan·View original on PubMed →
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Original publication title: Rapidly induced hypothermia with extracorporeal lung and heart assist (ECLHA) improves the neurological outcome after prolonged cardiac arrest in dogs.
- Species:
- dog
Plain-English summary
A group of 15 female dogs experienced cardiac arrest for 15 minutes and were then resuscitated using a special technique that supports the heart and lungs. They were divided into two groups: one group had their body temperature lowered quickly, while the other group had it lowered slowly. The dogs that were cooled rapidly showed better neurological recovery after 96 hours compared to those cooled slowly, although both groups had similar survival rates. This suggests that cooling dogs quickly after cardiac arrest may help improve their brain function.
People also search for: dog cardiac arrest treatment · dog resuscitation methods · improving dog neurological function after cardiac arrest
Abstract
PURPOSE: We reported previously that therapeutic hypothermia with extracorporeal lung and heart assist (ECLHA) improved neurological outcome after 15 min cardiac arrest (CA) in dogs, although 45 min was needed to achieve hypothermia. We now investigate whether rapidly induced hypothermia with ECLHA (RHE) would result in a better outcome than slowly induced hypothermia with ECLHA (SHE) in dogs. METHODS: Fifteen mongrel female dogs were divided into two groups: an RHE (n = 7) and an SHE (n = 8) group. Normothermic ventricular fibrillation was induced for 15 min and the animals were resuscitated by ECLHA. Rapid hypothermia was induced with a heat exchanger added to the ECLHA circuit in the RHE group, and by immersing the drainage tube of the ECLHA circuit in an ice water bath in the SHE group. Hypothermia (33 degrees C) was maintained for 20 h. The dogs were weaned from ECLHA at 24 h after resuscitation and treated for 96 h; neurological deficit scores (NDS) were measured throughout this period. RESULTS: It took 1.6+/-0.8 min to reach 33 degrees C in the RHE group and 49.5+/-12.1 min to reach 33 degrees C in the SHE group. There was no difference in survival rate between the two groups. The NDS at 96 h in the RHE group was better than that in the SHE group (26% (range: 10-28%) versus 32% (26-37%); p < 0.05) although there was no significant difference in NDS between the two groups until 72 h. CONCLUSION: Rapid hypothermic induction might be an important factor to improve neurological outcomes in prolonged CA models.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17097794/