Peer-reviewed veterinary case report
Cold saline flush of carotid artery to cool dog brain during cardiac
By Jeung, Kyung Woon et al.·Published in Resuscitation·2008·Department of Emergency Medicine, South Korea·View original on PubMed →
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Original publication title: Rapidly induced selective cerebral hypothermia using a cold carotid arterial flush during cardiac arrest in a dog model.
- Species:
- dog
Plain-English summary
A group of dogs experienced cardiac arrest, and researchers tested a method to cool their brains quickly using a cold saline flush in the carotid artery. After 9 minutes without blood flow, the dogs were resuscitated, and those that received the cold flush showed better neurological recovery compared to those that did not. While some dogs did not survive due to complications, the ones that received the cold treatment had significantly improved brain function scores after 72 hours. This suggests that rapidly cooling the brain during cardiac arrest may help improve outcomes.
People also search for: dog cardiac arrest treatment · dog brain cooling during CPR · canine cardiac arrest recovery
Abstract
PURPOSE: The present study was undertaken to determine whether flushing the carotid artery with normal saline at 4 degrees C (hypothermic carotid arterial flush, HCAF) during cardiac arrest can achieve selective cerebral hypothermia rapidly during cardiac arrest and improve cerebral outcome. METHODS: Ventricular fibrillation (VF) was induced in fourteen dogs and circulatory arrest was maintained for 9 min. Dogs were then resuscitated by cardiopulmonary resuscitation. The dogs were divided into two groups; a control group (n=7), which underwent precisely the same procedure as the experimental group but not HCAF, and an experimental group (HCAF group; n=7), which received HCAF from 8 min after the onset of VF. RESULTS: Two dogs in the control group and in the HCAF group died within 72 h after the recovery of spontaneous circulation (ROSC) due to extracerebral complications. The remaining 10 dogs survived to final evaluation at 72 h post-ROSC. In the HCAF group, tympanic temperature decreased from 37.7 degrees C (37.5-37.8) to 34 degrees C in 1 min (1-1.5) from the start of HCAF and was maintained below 34 degrees C until 6.5 min (3-12) after the start of HCAF, whereas oesophageal and rectal temperatures were maintained above 35 degrees C. Neurological deficit scores (0-100%) at 72 h post-ROSC were 42.4% (27.0-80.6) in the control group and 18.4% (14.0-36.0) in the HCAF group (p<0.05). CONCLUSION: HCAF induced selective cerebral hypothermia rapidly during cardiac arrest and improved neurological deficit scores after 9 min of no blood flow in the described canine cardiac arrest model.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18207624/