Peer-reviewed veterinary case report
Real-time monitoring of ONOO⁻ in cerebral ischemia-reperfusion injury mouse models using a hydrazine-based NIR fluorescent probe.
- Journal:
- Redox biology
- Year:
- 2025
- Authors:
- Shang, Jinting et al.
- Affiliation:
- Institute of Biomedical Sciences · China
- Species:
- rodent
Abstract
Accurate and selective techniques for visualizing endogenous peroxynitrite (ONOO) in cerebral ischemia-reperfusion injury (CIRI) models are essential for understanding its complex pathological processes. Here, we introduced a longwave fluorescent probe TJO for detecting ONOOrapidly and sensitively, with a low detection limit of 91 nM. Furthermore, TJO exhibits excellent fluorescence imaging capabilities, enabling detailed visualization of ONOO⁻ in CIRI mice model. This highlights its potential for real-time monitoring of ONOO⁻-related pathological conditions.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/39827589/