Peer-reviewed veterinary case report
Real-time PCR genotyping assay for canine trapped neutrophil syndrome and high frequency of the mutant allele in Border collies.
- Journal:
- Veterinary journal (London, England : 1997)
- Year:
- 2013
- Authors:
- Mizukami, Keijiro et al.
- Affiliation:
- Joint Faculty of Veterinary Medicine · Japan
- Species:
- dog
Abstract
Trapped neutrophil syndrome is an autosomal recessive inherited neutropenia in Border collies. The causative mutation is a 4base pair deletion in exon 19 of the canine VPS13B gene. In this study, a real-time PCR assay was developed and a genotyping survey was carried out in Border collies in Japan. The carrier frequency was 11.1%, suggesting that the mutant allele frequency is high enough to warrant measures to control and prevent the disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/22795605/