Peer-reviewed veterinary case report
Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals.
- Journal:
- Advanced drug delivery reviews
- Year:
- 2000
- Authors:
- van Drunen Littel-van den Hurk, S et al.
- Affiliation:
- Veterinary Infectious Disease Organization · Canada
- Species:
- rodent
Plain-English summary
Recent research is exploring DNA vaccines as a new way to protect farm animals from diseases. This method is promising because it can trigger strong immune responses, helping animals fight off various infections. While there have been some successful results in larger animals like cattle and pigs, most of the studies so far have been done in mice. The review discusses what we know about using DNA vaccines in farmed animals and highlights areas that need more work before these vaccines can be widely used, such as how to safely deliver them and how to combine them with other vaccines. Overall, the technology shows potential, but more research is needed before it can be fully implemented in farming.
Abstract
DNA-based vaccination constitutes one of the most recent approaches to vaccine development. This technology is in principle one of the most simple and yet versatile methods of inducing both humoral and cellular immune responses, as well as protection against a variety of infectious agents. However, although immune responses have been induced in a number of larger species, most information on the efficacy of DNA immunization has been generated in mice. In this review the information available to date about the use of DNA vaccines in farmed animals, including cattle, pigs and poultry, is presented. The areas that need specific attention in the future to bring this technology to the market are discussed, including the issues concerning delivery, safety, compatibility of plasmids in multivalent vaccines and the potential of using immune stimulants as part of a DNA vaccine.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/10967218/