Peer-reviewed veterinary case report
Receptor tyrosine kinase signaling regulates replication of the peste des petits ruminants virus.
- Journal:
- Acta virologica
- Year:
- 2015
- Authors:
- Chaudhary, K et al.
Abstract
In this study, we found out that blocking the receptor tyrosine kinase (RTK) signaling in Vero cells by tryphostin AG879 impairs the in vitro replication of the peste des petits ruminants virus (PPRV). A reduced virus replication in Trk1-knockdown (siRNA) Vero cells confirmed the essential role of RTK in the virus replication, in particular a specific regulation of viral RNA synthesis. These data represent the first evidence that the RTK signaling regulates replication of a morbillivirus.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25790054/