Peer-reviewed veterinary case report
Reclassifying small intestinal and cecal muscle tumors in 72 dogs
By Maas, Ceriel P H J et al.·Published in Veterinary surgery : VS·2007·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
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Original publication title: Reclassification of small intestinal and cecal smooth muscle tumors in 72 dogs: clinical, histologic, and immunohistochemical evaluation.
- Species:
- dog
Plain-English summary
A group of 72 dogs with tumors in the small intestine or cecum (the first part of the large intestine) were studied to better understand their conditions. Many of these dogs had symptoms like intestinal perforation and peritonitis, which is inflammation of the abdominal lining. After surgery to remove the tumors, most dogs had a good chance of not having the tumors come back, with 80% of small intestinal tumors and 83% of cecal tumors remaining free of recurrence after one year. The study found that the type of tumor didn't significantly affect survival, suggesting that surgical removal is an effective treatment for these tumors.
People also search for: dog intestinal tumor symptoms · cecal tumor surgery in dogs · dog tumor recurrence after surgery
Abstract
OBJECTIVES: To reclassify canine small intestinal and cecal leiomyoma (LM) and leiomyosarcoma (LMS) into smooth muscle and gastrointestinal stromal tumors (GIST) using histologic and immunohistochemical (IH) analysis and to report clinical findings and survival data. STUDY DESIGN: Retrospective review of cases. ANIMALS: Dogs (n=47) with small intestinal (40 LMS; 7 LM) and 25 dogs with cecal tumors (23 LMS; 2 LM). METHODS: Clinical and survival data were reviewed. Tissue sections were reevaluated for light-microscopic malignancy criteria and examined for expression of SMA, desmin, vimentin, S-100, and CD117 (KIT) by immunohistochemistry. RESULTS: Reclassification resulted in 2 LM, 9 LMS, 19 GIST, and 17 GIST-like tumors in the small intestine and 23 GIST and 2 GIST-like tumors in the cecum. GIST-like tumors were morphologic and IH identical to GIST but lacked KIT expression. No significant difference in survival was observed for tumor type, location, histologic, or IH characteristics; however, dogs with cecal tumors were significantly older in age, presented more commonly with intestinal perforation and peritonitis, and less commonly with weight loss. Cecal tumors had more histologic malignancy criteria than small intestinal tumors. After excision, 1 and 2 year recurrence-free periods were 80.1% and 67.2% for small intestinal and 83.3% and 61.9% for cecal tumors. CONCLUSION: Prognosis for intestinal tumors with histologic smooth muscle appearance is good after excision and not related to tumor type, location, histologic, or IH characteristics. CLINICAL RELEVANCE: Clinical importance could not be demonstrated for reclassification, but may be for future treatment, of intestinal smooth muscle or stromal tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17547593/