Peer-reviewed veterinary case report
West Nile virus vaccine protects dogs and cats from mosquito bites
By Karaca, K et al.·Published in Vaccine·2005·Merial Limited, United States·View original on PubMed →
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Original publication title: Recombinant canarypox vectored West Nile virus (WNV) vaccine protects dogs and cats against a mosquito WNV challenge.
- Species:
- cat
Plain-English summary
A group of dogs and cats were vaccinated against West Nile virus (WNV) to see if the vaccine could protect them from infection after being bitten by infected mosquitoes. The vaccinated pets showed a strong immune response, with all the dogs and most of the cats developing antibodies after the second vaccine dose. When exposed to the virus, none of the vaccinated dogs and only one vaccinated cat showed signs of infection, while many of the unvaccinated pets did. This vaccine could be an effective way to help prevent WNV in dogs and cats.
People also search for: West Nile virus vaccine for dogs · cat vaccine for mosquito-borne diseases · how to protect pets from West Nile virus
Abstract
The safety and efficacy of a canarypox vector expressing PrM and E genes of West Nile virus (WNV) (ALVAC-WNV) was evaluated in dogs and cats. One group of 17 dogs (vaccinated with 10(5.6) TCID(50)) and two groups of cats (groups 1 [n=14] vaccinated with 10(7.5) TCID(50) and 2 [n=8] 10(5.6) TCID(50)) were vaccinated twice at 28-day intervals. Fifteen dogs and eleven cats served as negative controls. The cats and dogs were challenged 120 and 135 days after the second immunization, respectively via the bites of Aedes albopictus mosquitoes infected with WNV. The first dose of vaccine induced a detectable antibody response in four dogs and five cats (one immunized with low and four with high doses). After the second dose, all the vaccinated dogs and all of the cats, immunized with high dose had detectable antibody titers, whereas only four of eight cats in the low dose group were seropositive. None of the vaccinated dogs and one vaccinated cat developed viremia following the WNV mosquito-challenge. In contrast, 14 of the 15 control dogs and 9 of the 11 control cats developed viremia. The experimental vaccine described in this study may be of value in the prevention of WNV infection in dogs and cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15893618/