Peer-reviewed veterinary case report
Recombinant(FAdV-E) penton base vaccination fails to confer protection against inclusion body hepatitis (IBH) in chickens.
- Journal:
- Avian pathology : journal of the W.V.P.A
- Year:
- 2023
- Authors:
- De Luca, Carlotta et al.
- Affiliation:
- University of Veterinary Medicine
Abstract
Inclusion body hepatitis (IBH) is a metabolic disease affecting chickens, associated with different serotypes of fowl adenovirus (FAdV). Experimentally tested vaccines against IBH include several capsid-based subunit vaccines, but not the penton base protein. In the present study, specific pathogen-free chickens were vaccinated with recombinant penton base expressed from each of two different FAdV serotypes (FAdV-7 and FAdV-8b), followed by challenge with a virulent IBH-causing strain. No protection was observed with either vaccine, possibly due to the low immunogenicity of each protein and their inability to induce neutralizing antibodies in the host.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37416969/