Peer-reviewed veterinary case report
New rabies virus vaccine protects dogs from deadly distemper infection
By Wang, Feng-Xue et al.·Published in Veterinary microbiology·2014·Institute of Special Economic Animals and Plants, China·View original on PubMed →
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Original publication title: Recombinant rabies virus expressing the H protein of canine distemper virus protects dogs from the lethal distemper challenge.
- Species:
- dog
Plain-English summary
A group of dogs was given a new vaccine made from a modified rabies virus that included a protein from the canine distemper virus (CDV). After receiving the vaccine, the dogs showed no signs of illness and developed antibodies against both the rabies virus and the CDV protein. When they were later exposed to a dangerous strain of CDV, all the vaccinated dogs remained healthy and protected. This promising vaccine could be important for protecting dogs and wildlife from distemper.
People also search for: dog distemper vaccine · canine distemper virus protection · rabies virus vaccine for dogs
Abstract
The rabies virus (RV) vector LBNSE expressing foreign antigens have shown considerable promise as vaccines against viral and bacteria diseases, which is effective and safe. We produced a new RV-based vaccine vehicle expressing 1.824 kb hemagglutinin (H) gene of the canine distemper virus (CDV) by reverse genetics technology. The recombinant virus LBNSE-CDV-H retained growth properties similar to those of vector LBNSE both in BSR and mNA cell culture. The H gene of CDV was expressed and detected by immunostaining. To compare the immunogenicity of LBNSE-CDV-H, dogs were immunized with each of these recombinant viruses by intramuscular (i.m.). The dogs were bled at third weeks after the immunization for the measurement of virus neutralizing antibody (VNA) and then challenged with virulent virus (ZJ 7) at fourth weeks. The parent virus (LBNSE) without expression of any foreign molecules was included for comparison. Dogs inoculated with LBNSE-CDV-H showed no any signs of disease and exhibited seroconversion against both RV and CDV H protein. The LBNSE-CDV-H did not cause disease in dogs and conferred protection from challenge with a lethal wild type CDV strain, demonstrating its potential value for wildlife conservation efforts. Together, these studies suggest that recombinant RV expressing H protein from CDV stimulated high levels of adaptive immune responses (VNA), and protected all dogs challenge infection.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25465178/