Peer-reviewed veterinary case report
Dog recovery after anesthesia with tiletamine-zolazepam, alfaxalone
By Hampton, Chiara E et al.·Published in Journal of the American Veterinary Medical Association·2019·View original on PubMed →
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Original publication title: Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane.
- Species:
- dog
Plain-English summary
Six healthy hound dogs were put under anesthesia for a procedure using different drugs to see how well they recovered afterward. The dogs were given anesthesia through an IV and then maintained with isoflurane gas. It turned out that the dogs recovered better when they were induced with propofol or alfaxalone compared to tiletamine-zolazepam. Overall, recovery from anesthesia was smooth and uncomplicated, especially with the use of propofol or alfaxalone, which led to quicker and better recovery scores.
People also search for: dog anesthesia recovery time · propofol vs tiletamine anesthesia dogs · hound dog anesthesia safety
Abstract
To compare characteristics of recovery from isoflurane anesthesia in healthy nonpremedicated dogs after anesthetic induction by IV administration of tiletamine-zolazepam with those observed after induction by IV administration of alfaxalone, ketamine-diazepam, or propofol.Prospective, randomized crossover study.6 healthy adult hounds.Each dog underwent the 4 treatments in random order with a ≥ 7-day washout period between anesthetic episodes. Anesthesia was induced by IV administration of the assigned induction drug or combination (each to effect in 25% increments of calculated dose) and maintained with isoflurane in oxygen for 60 minutes. Cardiorespiratory variables and end-tidal isoflurane concentration (ET) were measured just before isoflurane administration was discontinued. Dogs were observed and video recorded during recovery. Recovery characteristics were retrospectively scored from recordings by 3 raters. Interrater and intrarater reliability of scoring was assessed by intraclass correlation coefficient calculation. Linear and mixed ANOVAs were used to compare extubation times, recovery scores, and body temperature among treatments.Most cardiorespiratory variables, body temperature, ET, and time to extubation did not differ between tiletamine-zolazepam and other induction treatments. Recovery scores were lower (indicating better recovery characteristics) with propofol or alfaxalone than with tiletamine-zolazepam but did not differ between tiletamine-zolazepam and ketamine-diazepam treatments. Anesthetic episode number and EThad no effect on extubation time or recovery score. Intrarater and interrater correlations for recovery scores were excellent.Recovery of healthy dogs from anesthesia with isoflurane after induction with tiletamine-zolazepam was uncomplicated and had characteristics comparable to those observed following induction with ketamine-diazepam. However, recovery characteristics were improved when anesthesia was induced with propofol or alfaxalone.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31149881/