Peer-reviewed veterinary case report
Tumor recurrence after acridine orange therapy for dog nasal tumors
By Maruo, Takuya et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2021·Veterinary Teaching Hospital (Fukuyama, Japan·View original on PubMed →
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Original publication title: Recurrence analysis of intraoperative acridine orange-photodynamic therapy for dogs with intranasal tumors.
- Species:
- dog
Plain-English summary
A group of 38 dogs with intranasal tumors underwent a special treatment called acridine orange-photodynamic therapy (AO-PDT) during surgery. After treatment, most dogs had a median survival time of 24 months, but about half experienced a recurrence of their tumors within a year. The side effects were generally mild, including some swelling under the skin and nasal irritation. While AO-PDT showed promise in treating these tumors, improvements are needed to make the treatment more effective across the entire nasal area.
People also search for: dog nasal tumor treatment · acridine orange photodynamic therapy for dogs · dog intranasal tumor recurrence
Abstract
Intraoperative acridine orange-photodynamic therapy (AO-PDT) and cribriform plate irradiation are used to treat canine intranasal tumors. The purpose of this study was to evaluate the effects of AO-PDT on intranasal tumors and the recurrence rate of tumors after this treatment. Treatments with AO-PDT were performed on 38 dogs through a narrow window of the dorsal nasal cavity. The median progression-free interval was 12 mo and recurrence was detected in 21 dogs. Based on computed tomography, recurrence in 16 dogs was biased to the following areas: lateral (= 10), medial (= 2), ventral (= 0), rostral (= 0), and caudal (= 8). Side effects were mild and included subcutaneous emphysema and rhinitis. The median survival time was 24 mo. Although AO-PDT with cribriform irradiation is an effective treatment for intranasal tumors, AO-PDT techniques should be improved to treat the nasal cavity more uniformly and thoroughly.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34602642/