Peer-reviewed veterinary case report
Recurrence rates after surgery for grade II mast cell tumors in dogs
By Smith, J et al.·Published in Veterinary and comparative oncology·2017·Department of Medical Oncology, United States·View original on PubMed →
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Original publication title: Recurrence rates and clinical outcome for dogs with grade II mast cell tumours with a low AgNOR count and Ki67 index treated with surgery alone.
- Species:
- dog
Plain-English summary
An 8-year-old dog with a grade II mast cell tumor (a type of skin tumor) underwent surgery to remove the tumor. After surgery, 27% of the dogs in the study experienced a recurrence of the tumor, but the majority had low levels of tumor growth activity. The study found that dogs with incomplete removal of the tumor had similar recurrence rates to those with complete removal, suggesting that additional treatments may not be needed for dogs with low-risk tumors that are not fully excised.
People also search for: dog mast cell tumor treatment · grade II mast cell tumor prognosis · dog tumor recurrence after surgery
Abstract
Grade II mast cell tumours (MCT) are tumours with variable biologic behaviour. Multiple factors have been associated with outcome, including proliferation markers. The purpose of this study was to determine if extent of surgical excision affects recurrence rate in dogs with grade II MCT with low proliferation activity, determined by Ki67 and argyrophilic nucleolar organising regions (AgNOR). Eighty-six dogs with cutaneous MCT were evaluated. All dogs had surgical excision of their MCT with a low Ki67 index and combined AgNORxKi67 (Ag67) values. Twenty-three (27%) dogs developed local or distant recurrence during the median follow-up time. Of these dogs, six (7%) had local recurrence, one had complete and five had incomplete histologic margins. This difference in recurrence rates between dogs with complete and incomplete histologic margins was not significant. On the basis of this study, ancillary therapy may not be necessary for patients with incompletely excised grade II MCT with low proliferation activity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25643820/