Peer-reviewed veterinary case report
Oxidative stress and antioxidants in dogs with mast cell tumors
By Finotello, R et al.·Published in Veterinary and comparative oncology·2014·Department of Veterinary Clinics, United Kingdom·View original on PubMed →
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Original publication title: Redox status evaluation in dogs affected by mast cell tumour.
- Species:
- dog
Plain-English summary
A group of 23 dogs with mast cell tumors (a type of skin cancer) showed signs of oxidative stress, which means their bodies were struggling to fight off damage from harmful molecules. These dogs had higher levels of reactive oxygen metabolites and lower antioxidant activity compared to 10 healthy dogs. This suggests that dogs with newly diagnosed mast cell tumors may have an altered ability to manage oxidative stress. Understanding this could help veterinarians develop better treatment plans in the future.
People also search for: dog mast cell tumor treatment · signs of cancer in dogs · oxidative stress in dogs
Abstract
Oxidative stress status has been evaluated in depth in human medicine and its role in carcinogenesis has been clearly established. The purpose of this prospective study was to evaluate antioxidant concentrations and oxidative stress in dogs with mast cell tumours (MCTs) that had received no previous treatments, and to compare them to healthy controls. In 23 dogs with mast cell tumour and 10 healthy controls, oxidative status was assessed using the Reactive Oxygen Metabolites-derived compounds (d-ROMs) test, antioxidant activity was measured by the Biological Antioxidant Potential (BAP) test, and α-tocopherol levels were evaluated using high-performance liquid chromatography and ultraviolet analysis. At baseline, dogs with MCT had significantly higher d-ROMs (P < 0.00001) and lower BAP (P < 0.0002) compared with healthy controls. However, no significant difference was observed for α-tocopherol (P = 0.95). Results suggest that oxidative stress pattern and oxidative defence barrier are altered in dogs with newly diagnosed MCT compared with control dogs. Future studies are needed in order to assess the prognostic role of oxidative stress and to evaluate the impact of different therapeutic approaches.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22823560/