Peer-reviewed veterinary case report
Reduced threshold for cortical spreading depression in female mice.
- Journal:
- Annals of neurology
- Year:
- 2007
- Authors:
- Brennan, Kevin C et al.
- Affiliation:
- Department of Neurology · United States
- Species:
- rodent
Abstract
The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17474110/