Peer-reviewed veterinary case report
Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
- Journal:
- Annals of the New York Academy of Sciences
- Year:
- 2007
- Authors:
- Blankenhorn, Elizabeth P et al.
- Affiliation:
- Department of Microbiology and Immunology · United States
- Species:
- rodent
Abstract
Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC-identical normal WF rats, Iddm4(d) sensitively and specifically predicts induced diabetes. We report a new diabetes-susceptible subcongenic line that carries Iddm4 in a < 2.6 megabase interval. Candidate genes include the T cell receptor beta chain variable (TCRVbeta) family. We found that TCRVbeta4 in WF rats contains a stop codon, whereas 5/5 diabetes-susceptible rat strains express TCRVbeta4. We conclude that Iddm4-mediated diabetes resistance in rats may be due to a recessive protective mutation in TCRVbeta4.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17376830/