Peer-reviewed veterinary case report
Basic fibroblast growth factor helps heal dog jaw bone defects
By Shirakata, Yoshinori et al.·Published in Journal of clinical periodontology·2010·Department of Periodontology, Japan·View original on PubMed →
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Original publication title: Regenerative effect of basic fibroblast growth factor on periodontal healing in two-wall intrabony defects in dogs.
- Species:
- dog
Plain-English summary
Four Beagle dogs underwent surgery to create small bone defects around their teeth to test a new treatment for periodontal (gum) healing using a substance called basic fibroblast growth factor (bFGF). After eight weeks, the dogs showed more bone growth in the areas treated with bFGF compared to other treatments, but the healing was similar to established treatments like enamel matrix derivative (EMD) and platelet-derived growth factor with beta-tricalcium phosphate (PDGF/beta-TCP). This suggests that bFGF could be a promising option for helping dogs recover from periodontal issues.
People also search for: dog gum disease treatment · Beagle periodontal healing · basic fibroblast growth factor for dogs
Abstract
AIM: The aim of the present study was to evaluate the effect of a basic fibroblast growth factor (bFGF) candidate treatment on periodontal healing in two-wall intrabony defects in dogs. MATERIALS AND METHODS: Two-wall intrabony defects (5 x 5 x 5 mm) were created surgically on the distal and mesial sides of bilateral mandibular second and fourth premolars in four Beagle dogs. bFGF, enamel matrix derivative (EMD) and platelet-derived growth factor with beta-tricalcium phosphate (PDGF/beta-TCP) treatments, and sham-surgery (OFD) were rotated among the four defects in each animal, EMD and PDGF/beta-TCP serving as benchmark controls. The animals were euthanized for radiographic and histologic evaluation at 8 weeks. RESULTS: Bone formation was significantly greater in the bFGF group (4.11 +/- 0.77 mm) than in the EMD (3.32 +/- 0.71 mm; p<0.05) and OFD (3.09 +/- 0.52 mm; p<0.01) groups. The EMD (4.59 +/- 1.19 mm) and PDGF/beta-TCP (4.66 +/- 0.7 mm) groups exhibited significantly greater cementum regeneration with periodontal ligament-like tissue than the OFD group (2.96 +/- 0.69 mm; p<0.01). No significant differences were observed between the bFGF and the PDGF/beta-TCP groups in any of the histometric parameters. CONCLUSIONS: The candidate bFGF treatment supported periodontal regeneration comparable with that of established benchmarks: EMD and PDGF/beta-TCP.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20447261/