Peer-reviewed veterinary case report
Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience.
- Journal:
- European archives of psychiatry and clinical neuroscience
- Year:
- 2016
- Authors:
- Yang, Bangkun et al.
- Affiliation:
- Chiba University Center for Forensic Mental Health · Japan
- Species:
- rodent
Abstract
Using learned helplessness (LH) model of depression, we measured protein expression of brain-derived neurotrophic factor (BDNF) pro-peptide, BDNF precursors (proBDNF and preproBDNF) in the brain regions of LH (susceptible) and non-LH rats (resilience). Expression of preproBDNF, proBDNF and BDNF pro-peptide in the medial prefrontal cortex of LH rats, but not non-LH rats, was significantly higher than control rats, although expression of these proteins in the nucleus accumbens of LH rats was significantly lower than control rats. This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/27094192/