Peer-reviewed veterinary case report
Horse with lymphoma and ovarian tumor - what happened after surgery?
By Henson, K L et al.·Published in Journal of the American Veterinary Medical Association·1998·Department of Physiological Sciences, United States·View original on PubMed →
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Original publication title: Regression of subcutaneous lymphoma following removal of an ovarian granulosatheca cell tumor in a horse.
- Species:
- horse
Plain-English summary
A 9-year-old Arabian mare was brought in for multiple lumps under her skin and issues with infertility. Tests revealed she had a type of cancer called histiolymphocytic lymphoma and a tumor on her left ovary. After the ovarian tumor was surgically removed, the skin lumps started to shrink and eventually disappeared. However, they returned after the mare was given a synthetic hormone treatment. Further tests suggested that the skin lymphoma might be influenced by hormonal changes related to her reproductive cycle.
People also search for: horse skin lumps · equine lymphoma treatment · ovarian tumor in horses · horse infertility causes
Abstract
A 9-year-old Arabian mare was admitted for evaluation of multiple subcutaneous nodules and infertility. Fine-needle aspiration of one of the subcutaneous nodules resulted in a cytologic diagnosis of histiolymphocytic lymphoma. Palpation per rectum and transrectal ultrasonography revealed a mass associated with the left ovary. Excision of the ovarian tumor was performed, and a histopathologic diagnosis of granulosa-theca cell tumor was made. After removal of the granulosa-theca cell tumor, subcutaneous nodules regressed. The referring veterinarian reported that the nodules had also disappeared and then recurred after administration of a synthetic progestin. To further characterize the lymphoma and investigate this possible hormonal relationship, immunophenotyping and estrogen and progesterone receptor assays were performed. The subcutaneous lymphoma was classified as a T-cell rich B-cell lymphoma, results of estrogen receptor assays were negative, and results of progesterone receptor assays were positive. Clinical observations of subcutaneous lymphoma in horses indicate that the waxing and waning nature of these tumors may be associated with the estrous cycle, pregnancy, foaling, and lactation. Clinical observations and identification of progesterone receptors suggest that a relationship between serum steroid hormone concentrations, such as estrogen and progesterone, and subcutaneous lymphoma may exists.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/9589129/