Peer-reviewed veterinary case report
Severe insulin resistance linked to anti-insulin antibodies
By Komiya, Takumi et al.·Published in The Journal of veterinary medical science·2021·School of Veterinary Nursing & Technology, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Relationship between anti-insulin antibody production and severe insulin resistance in a diabetic cat.
- Species:
- cat
Plain-English summary
A 5-year-old male domestic shorthair cat was brought in for severe dehydration and diabetic ketoacidosis, a serious complication of diabetes. Despite standard treatments, the cat continued to struggle due to severe insulin resistance caused by high levels of anti-insulin antibodies. The veterinarian started the cat on prednisolone to help reduce these antibodies, which led to improvements in the cat's activity and appetite. With the addition of two types of insulin injections, the cat achieved better blood sugar control and began to recover.
People also search for: diabetic cat treatment · cat insulin resistance · diabetic ketoacidosis in cats · prednisolone for cats · cat appetite increase after insulin
Abstract
A 5-year-old castrated male domestic shorthair cat was diagnosed with diabetic ketoacidosis and severe insulin resistance. Although the conventional treatment for diabetic ketoacidosis was provided, the cat required frequent hospitalization because of severe dehydration and repeated diabetic ketoacidosis. We detected anti-insulin antibodies for human in this cat. Serum insulin-binding IgG levels were markedly elevated compared with those in healthy cats and other diabetic cats. We initiated prednisolone to suppress the effects of anti-insulin antibodies. After initiation of prednisolone, the cat was gradually recovered with increasing activity and appetite. Furthermore, satisfactory glycemic control was achieved with combined subcutaneous injection of insulin detemir and insulin degludec.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33840723/