Peer-reviewed veterinary case report
How SDMA and other markers relate to kidney disease in cats
By Simona Grelová et al.·Published in Animals·2022·Small Animal Clinic, University of Veterinary Medicine and Pharmacy, 04001 Košice, Slovakia, CH·View original on DOAJ →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Relationship between FGF 23, SDMA, Urea, Creatinine and Phosphate in Relation to Feline Chronic Kidney Disease
- Species:
- cat
Plain-English summary
A group of older cats was studied to understand how different blood markers relate to chronic kidney disease (CKD). Out of 99 cats, 48 were diagnosed with CKD, while the rest were healthy. The researchers found that cats with CKD had higher levels of a protein called FGF 23 compared to healthy cats, but this protein didn't correlate with another marker called SDMA. However, phosphate levels were strongly linked to both SDMA and other kidney function markers, suggesting that phosphate could be important in tracking CKD progression.
People also search for: cat kidney disease symptoms · high phosphate levels in cats · SDMA test for cats · chronic kidney disease in older cats
Abstract
Chronic kidney disease (CKD) is a common diagnosis in older cats, and its prevalence increases with age. Conventional indirect biomarkers of glomerular filtration rate (GFR) have their limitations, and are not efficient in detecting early decreases in glomerular filtration rate. Recently, symmetric dimethylarginine (SDMA) concentrations have been proposed as a novel biomarker of GFR for the early detection of CKD. This study discusses the relationship between SDMA, FGF 23 and previously used indicators of kidney function, mainly creatinine, urea and phosphate. Ninety-nine cats were included in this study. Based on their SDMA values, 48 cats had CKD and the remaining 51 cats were used as a healthy control group. Serum of these cats was assayed for creatinine, urea and phosphate concentrations as well as FGF 23 values, and correlations between them were evaluated. Cats with CKD had higher FGF 23 concentrations than healthy cats, and no correlation was found between FGF 23 and SDMA, nor between FGF 23 and phosphate. On the other hand, phosphate strongly correlated with SDMA, urea and creatinine, making it a possible independent factor of CKD progression.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on DOAJ: https://doi.org/10.3390/ani12172247