Peer-reviewed veterinary case report
Changes in blood HDL and enzyme levels in dogs with babesiosis
By Rossi, G et al.·Published in Research in veterinary science·2014·Department of Veterinary Sciences and Public Health (DiVet), Italy·View original on PubMed →
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Original publication title: Relationship between paraoxonase 1 activity and high density lipoprotein concentration during naturally occurring babesiosis in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with babesiosis, a disease that can cause serious health issues, had lower levels of a protective protein called paraoxonase 1 (PON1) and high-density lipoproteins (HDL) when they were first seen by the vet. After starting treatment, the dogs showed improvement: their HDL levels went up within a day, and PON1 levels increased by the end of the week. This indicates that treatment helped restore some of the protective factors in their blood. Monitoring these levels can help vets understand how well the dogs are responding to treatment.
People also search for: dog babesiosis treatment · low HDL in dogs · paraoxonase 1 levels in dogs
Abstract
Paraoxonase 1 (PON1) is a negative acute phase protein bound to high density lipoproteins (HDL) and during the acute phase response (APR) protects HDL from peroxidation. The aim of this study was to assess the relationship between PON1 and HDL in canine babesiosis, a disease characterized by oxidative damages and by an APR. PON1, HDL and C-reactive protein (CRP), were measured in blood collected from 15 controls and 29 dogs with babesiosis sampled at admission, and on days 1 and 7 after treatment. At admission, PON1 and HDL were significantly lower in affected dogs. HDL concentration increased at day 1 while PON1 increased and CRP decreased at day 7. This suggests that the decrease of PON1 at admission is in part due to an increased consumption, the decreased HDL may depend on lipid peroxidation and its rapid increase after treatment may depend on the antioxidant activity of PON1.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25104322/