Peer-reviewed veterinary case report
Body weight does not affect cyclosporine dose in dogs with atopic
By Cohen, Loren et al.·Published in Journal of the American Animal Hospital Association·2014·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Relationship of body weight to maintenance cyclosporine a dose in canine atopic dermatitis.
- Species:
- dog
Plain-English summary
A group of dogs with atopic dermatitis (a skin allergy) were treated with cyclosporine A, a medication that helps reduce itching and inflammation. The study looked at whether a dog's weight affected how much of the medication they needed. After analyzing data from 77 dogs over several months, researchers found that the dose of cyclosporine did not need to change based on the dog's weight. All dogs showed improvement in their symptoms, with reduced itching and less need for other medications.
People also search for: dog skin allergy treatment · cyclosporine A dosage for dogs · why is my dog itching · atopic dermatitis in dogs · dog allergy medication effectiveness
Abstract
Cyclosporine A (CsA) is a commonly prescribed and effective therapy for canine atopic dermatitis. The purpose of this study was to investigate the potential relationship between patient body weight and CsA dosing. Seventy-seven cases of canine atopic dermatitis managed between 2000 and 2011 were evaluated retrospectively. Duration of CsA therapy was at least 16 wk. Groups analyzed included the study population as a whole, those treated with only CsA, and those treated with both CsA and metoclopramide. The division between small and large dogs was set at 15 kg. Descriptive analysis, two-way analysis of variance, Pearson correlations, and a Student t test were used to analyze data. There were no significant differences between CsA dose and body weight regardless of method of analysis. Concurrent corticosteroid use, other medication use, and pruritus score were also analyzed over the study period. There was a significant decrease in CsA dose, corticosteroid dose, medication score, and pruritus score between the time points for all patients, but no significant relationship between those changes and body weight. These study findings suggest that differential CsA dosing is not warranted based on body weight.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24659725/