Peer-reviewed veterinary case report
Serum leptin levels in dogs with pituitary hyperadrenocorticism
By Lee, S et al.·Published in The Journal of small animal practice·2019·Department of Veterinary Clinical Sciences, South Korea·View original on PubMed →
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Original publication title: Relationship of serum leptin concentration with pituitary-dependent hyperadrenocorticism and cholestatic disease in dogs.
- Species:
- dog
Plain-English summary
A group of dogs with pituitary-dependent hyperadrenocorticism (a hormonal disorder) and varying degrees of liver bile flow issues were studied to see how their leptin levels compared to healthy dogs. The dogs with the hormonal disorder had higher leptin levels, especially those with more severe liver issues. This suggests that leptin levels might increase with the severity of liver problems in these dogs. Understanding these changes could help veterinarians better manage dogs with these conditions.
People also search for: dog pituitary-dependent hyperadrenocorticism symptoms · elevated leptin in dogs · dog gall bladder mucocoele treatment
Abstract
OBJECTIVES: To measure serum leptin concentration in dogs with pituitary-dependent hyperadrenocorticism and varying degrees of cholestatic disease and determine whether serum levels differed between dogs with pituitary-dependent hyperadrenocorticism and those with gall bladder mucocoele. MATERIALS AND METHODS: Client-owned healthy dogs (n=20), dogs diagnosed with gall bladder mucocoele (n=20) and dogs diagnosed with pituitary-dependent hyperadrenocorticism (n=60) were enrolled. Only dogs of normal body condition score were included. Dogs with pituitary-dependent hyperadrenocorticism were divided into three groups according to the severity of cholestatic disease: normal gall bladder (n=20), cholestasis (n=20) and gall bladder mucocoele (n=20). Serum leptin levels were measured using sandwich enzyme-linked immunosorbent assay. RESULTS: Serum concentrations of leptin were similar between dogs with gall bladder mucocoele and those with pituitary-dependent hyperadrenocorticism accompanied by gall bladder mucocoele; these concentrations were significantly higher than those in healthy control dogs. In dogs with pituitary-dependent hyperadrenocorticism, circulating leptin concentration significantly increased with the severity of cholestasis: higher in the cholestasis group than the normal gall bladder group and higher in the gall bladder mucocoele group than the cholestasis group. CLINICAL SIGNIFICANCE: Elevated circulating leptin concentration was associated with canine pituitary-dependent hyperadrenocorticism and gall bladder mucocoele. Homeostatic imbalance of leptin concentration might be associated with severity of cholestatic disease in pituitary-dependent hyperadrenocorticism.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31276206/