Peer-reviewed veterinary case report
Dog with kidney collecting duct cancer that spread to lungs and spleen
By Kobayashi, N et al.·Published in Veterinary pathology·2008·Department of Molecular Pathology, Japan·View original on PubMed →
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Original publication title: Renal collecting duct carcinoma in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old male mongrel dog developed a severe cough and stopped eating, leading to his death within three months. An autopsy revealed a large tumor in his right kidney and several nodules in his lungs, chest wall, and spleen. The tumor was diagnosed as renal collecting duct carcinoma, a type of kidney cancer that can spread to other parts of the body. Unfortunately, due to the advanced stage of the disease, there was no successful treatment, and the dog did not survive.
People also search for: dog cough and not eating · kidney cancer in dogs · symptoms of dog kidney disease
Abstract
An 8-year-old, male, mongrel dog developed severe cough and anorexia and died within 3 months. Autopsy revealed an invasive grayish-white mass in the right kidney and multiple nodules in the lungs, thoracic wall, and spleen. Histologically, the renal mass and the other nodules were mainly composed of papillotubular structures lined by oval-to-polygonal pleomorphic cells. The cells were reactive with DBA, PNA, and UEA-1 lectins and positive for vimentin but negative for CD10 and high molecular weight cytokeratin. Because of its histological, histochemical, and immunohistochemical similarities with human collecting duct carcinoma (CDC), a diagnosis of renal collecting duct carcinoma with pulmonary, thoracic, and splenic metastases was established. To our knowledge, this is the first case report of CDC in animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18587095/