Peer-reviewed veterinary case report
Renin-angiotensin system activity in hyperthyroid cats with high
By Williams, T L et al.·Published in Journal of veterinary internal medicine·2013·Department of Veterinary Clinical Sciences, United Kingdom·View original on PubMed →
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Original publication title: Renin-angiotensin-aldosterone system activity in hyperthyroid cats with and without concurrent hypertension.
- Species:
- cat
Plain-English summary
A group of 99 hyperthyroid cats was studied to understand how their bodies react to high blood pressure, which can occur before or after treatment for hyperthyroidism. The researchers measured certain hormone levels related to blood pressure regulation and found that while these hormones were activated in hyperthyroid cats, they did not directly cause high blood pressure. After treatment, some cats showed a decrease in hormone levels, indicating a change in their condition. This suggests that even though hyperthyroid cats may have high blood pressure, the hormonal system involved may not be functioning normally.
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Abstract
BACKGROUND: Hypertension is present in some hyperthyroid cats at diagnosis or can develop after treatment for hyperthyroidism. Activation of the renin-angiotensin-aldosterone system (RAAS) could be involved in the pathogenesis of hypertension. HYPOTHESIS: Hyperthyroid cats that develop hypertension before or after treatment for hyperthyroidism will have greater RAAS activation than normotensive cats. ANIMALS: Ninety-nine hyperthyroid cats. METHODS: Retrospective case-control study. Plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were measured in untreated hyperthyroid hypertensive cats (HT-Pre group), initially normotensive hyperthyroid cats that develop hypertension after treatment (HT-Post group), and hyperthyroid cats that are normotensive (NT group). Data are presented as median [25th, 75th percentile]. RESULTS: Baseline PRA was not significantly different among the 3 groups (HT-Pre group 1.50 [0.05, 2.37] ng/mL/h, HT-Post group 0.66 [0.17, 2.31] ng/mL/h, NT group 1.11 [0.57, 2.18] ng/mL/h; P = .44). PRA decreased significantly after treatment in the NT group (1.09 [0.53, 2.47] versus 0.22 [0.05, 0.76] ng/mL/h; P < .001) and the HT-Post group (0.71 [0.17, 2.33] versus 0.28 [0.07, 0.57] ng/mL/h; P = .006). Baseline PAC was not significantly different among the 3 groups (HT-Pre group 72.2 [40.0, 145.6] pg/mL, HT-Post group 69.7 [43.3, 142.6] pg/mL, NT group 109.0 [68.2, 184.6] pg/mL; P = .10). PAC decreased significantly after treatment in the NT group (114.4 [56.6, 204.1] versus 59.5 [32.4, 98.2] pg/mL; P < .001) but did not change significantly in the HT-Post group (61.2 [44.9, 124.0] versus 58.4 [42.0, 97.7] pg/mL; P = .59). CONCLUSIONS AND CLINICAL IMPORTANCE: RAAS activation occurs in hyperthyroid cats, but is not associated with the development of hypertension. PAC is not influenced by changes in PRA in hyperthyroid cats that develop hypertension after treatment, perhaps indicating RAAS dysfunction in these cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23517505/