Peer-reviewed veterinary case report
Repeated gene therapy injections to treat gray collie dog cyclic
By Yanay, Ofer et al.·Published in Human gene therapy·2012·Department of Pediatrics, United States·View original on PubMed →
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Original publication title: Repeated lentivirus-mediated granulocyte colony-stimulating factor administration to treat canine cyclic neutropenia.
- Species:
- dog
Plain-English summary
A gray collie with cyclic neutropenia (a condition causing low white blood cell counts) received repeated injections of a special treatment called G-CSF-lentivirus to help boost its immune system. After several doses, the dog's white blood cell counts significantly increased and remained elevated for over five months, helping it stay healthy and gain weight. The treatment was well-tolerated, and the dog showed no adverse effects during nearly three years of administration. This suggests that G-CSF-lentivirus could be an effective option for dogs with similar blood cell issues.
People also search for: gray collie cyclic neutropenia treatment · dog low white blood cell count · G-CSF for dogs
Abstract
Cyclic neutropenia occurs in humans and gray collie dogs, is characterized by recurrent neutropenia, and is treated by repeated injections of recombinant granulocyte colony-stimulating factor (rG-CSF). As dose escalation of lentivirus may be clinically necessary, we monitored the outcome of four sequential intramuscular injections of G-CSF-lentivirus (3 × 10(7) IU/kg body weight) to a normal dog and a gray collie. In the normal dog absolute neutrophil counts were significantly increased after each dose of virus, with mean levels of 27.75 ± 3.00, 31.50 ± 1.40, 35.05 ± 1.68, and 43.88 ± 2.94 × 10(3) cells/μl, respectively (p<0.001), and elevated neutrophil counts of 31.18 ± 7.81 × 10(3) cells/μl were maintained for more than 6 years with no adverse effects. A gray collie dog with a mean count of 1.94 ± 1.48 × 10(3) cells/μl received G-CSF-lentivirus and we observed sustained elevations in neutrophil levels for more than 5 months with a mean of 26.00 ± 11.00 × 10(3) cells/μl, significantly increased over the pretreatment level (p<0.001). After the second and third virus administrations mean neutrophil counts of 15.80 ± 6.14 and 11.52 ± 4.90 × 10(3) cells/μl were significantly reduced compared with cell counts after the first virus administration (p<0.001). However, after the fourth virus administration mean neutrophil counts of 15.21 ± 4.50 × 10(3) cells/μl were significantly increased compared with the previous administration (p<0.05). Throughout the nearly 3 years of virus administrations the dog gained weight, was healthy, and showed neutrophil counts significantly higher than pretreatment levels (p<0.001). These studies suggest that patients with cyclic and other neutropenias may be treated with escalating doses of G-CSF-lentivirus to obtain a desired therapeutic neutrophil count.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22845776/