Peer-reviewed veterinary case report
Effectiveness of nasal clotrimazole for treating dog nasal
By Pomrantz, Jill S & Johnson, Lynelle R·Published in Journal of the American Veterinary Medical Association·2010·Veterinary Medical Teaching Hospital, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Repeated rhinoscopic and serologic assessment of the effectiveness of intranasally administered clotrimazole for the treatment of nasal aspergillosis in dogs.
- Species:
- dog
Plain-English summary
A group of 23 dogs with nasal aspergillosis, a fungal infection in the nose, were treated with an intranasal solution of clotrimazole. After the first treatment, nearly half of the dogs showed no signs of the disease, and overall, about 67% of the dogs responded well to the treatment, although some experienced a recurrence of the infection later on. The study found that monitoring nasal discharge or blood tests was not helpful in predicting how well the treatment was working, so follow-up examinations are important to check for improvement.
People also search for: dog nasal discharge treatment · clotrimazole for dog nasal aspergillosis · dog fungal infection symptoms
Abstract
OBJECTIVE: To determine the role of rhinoscopic evaluation and repeated serologic testing in assessing the success rate of intranasally administered clotrimazole for treatment of dogs with nasal aspergillosis. DESIGN: Prospective case series. ANIMALS: 23 dogs with nasal aspergillosis. PROCEDURES: Dogs with nasal aspergillosis were treated with an intranasal infusion of 1% clotrimazole solution. Response to treatment was assessed with repeated rhinoscopic evaluation, with histologic examination and fungal culture when available. Results of repeated serologic testing for aspergillosis were monitored throughout the treatment course. RESULTS: 11 of the 23 (48%) dogs had no rhinoscopic evidence of disease after the first treatment. Three of 7 dogs were free of disease after the second treatment, and 1 of 3 dogs was free after the third treatment. Presence or absence of nasal discharge and results of repeated serologic testing were not consistent with disease status. Overall, the efficacy of intranasally administered clotrimazole for treatment of nasal aspergillosis could be confirmed in 15 of 17 dogs. Delayed recurrence or reinfection was confirmed in 3 of 15 dogs. When recurrences were taken into account, the success rate was 67% (12/15 dogs). CONCLUSIONS AND CLINICAL RELEVANCE: Clinical signs were not predictive of disease state, and follow-up rhinoscopy is recommended to assess response to treatment. The success rate of intranasally administered clotrimazole was similar to rates in previous reports; however, the number of dogs with recurrent disease was relatively high. Monitoring of the results of serologic testing is not recommended for use in determining response to treatment.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20367042/