Peer-reviewed veterinary case report
Replacing microglia to treat Alzheimer's disease.
- Journal:
- Cell stem cell
- Year:
- 2023
- Authors:
- Jiang, Peng & Jin, Mengmeng
- Affiliation:
- Department of Cell Biology and Neuroscience · United States
Abstract
In this issue of Cell Stem Cell, Yoo et al.report that replacing Trem2 knockout microglia with Trem2 wild-type microglia-like cells derived from systemically transplanted hematopoietic cells rectifies microglial dysfunction in a mouse model of amyloidosis. These findings highlight the potential of microglia replacement therapy for Alzheimer's disease treatment.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/37541204/