Peer-reviewed veterinary case report
Repurposing Ivacaftor for treatment of Staphylococcus aureus infections.
- Journal:
- International journal of antimicrobial agents
- Year:
- 2017
- Authors:
- Thakare, Ritesh et al.
- Affiliation:
- Department of Microbiology · India
Abstract
Drug repurposing of non-antimicrobials is a novel method to augment a seriously depleted drug pipeline for targeting drug-resistant pathogens. This article highlights the potent antimicrobial activity of Ivacaftor against Staphylococcus aureus, including vancomycin- and other multidrug-resistant strains. The potent activity of Ivacaftor in vivo is also demonstrated in a murine neutropenic thigh infection model. Taken together, these results support the potential of Ivacaftor as an antimicrobial agent for the treatment of staphylococcal infections.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/28694231/