Peer-reviewed veterinary case report
Resident lymphocytes in the dermis of the normal dorsolateral thoracic skin of alpacas.
- Journal:
- Veterinary dermatology
- Year:
- 2014
- Authors:
- Edginton, Heather D et al.
- Affiliation:
- Department of Clinical Sciences · United States
Abstract
BACKGROUND: Small numbers of resident T lymphocytes are present in the dermis of normal skin of humans, cattle and sheep. HYPOTHESIS/OBJECTIVES: We wanted to determine the prevalence, numbers and immunophenotype of lymphocytes in the dermis of healthy skin from alpacas. ANIMALS: Skin biopsy specimens were collected from the dorsolateral thorax of 31 alpacas with normal skin. METHODS: Skin biopsy specimens were evaluated for the prevalence and numbers of CD3+ and CD79a+ lymphocytes. RESULTS: Resident CD3+ and CD79a+ lymphocytes were found around the superficial and deep dermal blood vessels. The CD3+ lymphocytes were more numerous than CD79a+ lymphocytes. Both CD3+ and CD79a+ lymphocytes were more numerous around superficial dermal blood vessels. CONCLUSIONS AND CLINICAL IMPORTANCE: Resident CD3+ and CD79a+ lymphocytes are present around superficial and deep dermal blood vessels in normal skin from alpacas; hence, the presence of lymphocytes in these locations without obvious features of inflammation must be interpreted cautiously when evaluating skin biopsy specimens from alpacas with skin disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24382011/