Peer-reviewed veterinary case report
Resistance of methicillin-resistant Staphylococcus in dogs
By Kizerwetter-Świda, Magdalena et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2016·Department of Preclinical Sciences·View original on PubMed →
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Original publication title: Resistance of canine methicillin-resistant Staphylococcus pseudintermedius strains to pradofloxacin.
- Species:
- dog
Plain-English summary
A study found that most strains of methicillin-resistant Staphylococcus pseudintermedius (MRSP), a common skin infection in dogs, are resistant to a new antibiotic called pradofloxacin. Out of 38 MRSP samples tested, 33 showed resistance to pradofloxacin, meaning they wouldn't respond to this treatment. Only two samples were sensitive to all tested antibiotics, including pradofloxacin. This suggests that if your dog has a skin infection caused by MRSP, pradofloxacin may not be effective, and your vet might need to consider other treatment options based on specific tests.
People also search for: dog skin infection treatment · MRSP antibiotic resistance · pradofloxacin for dogs
Abstract
We investigated in vitro activity of a novel veterinary fluoroquinolone, pradofloxacin, against methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates and compared with other fluoroquinolones. A total of 38 MRSP isolates were subjected to agar disk diffusion tests for sensitivity to pradofloxacin, orbifloxacin, marbofloxacin, enrofloxacin, and ciprofloxacin. The minimal inhibitory concentration (MIC) values of pradofloxacin, ciprofloxacin, and enrofloxacin were determined. Mutations in the genes encoding DNA gyrase subunit A (GyrA) and topoisomerase IV (GrlA) proteins associated with fluoroquinolone resistance were studied by an analysis of partial sequences of the genes encoding these proteins. Two MRSP isolates were susceptible in disk diffusion and microdilution test to all fluoroquinolones tested, including pradofloxacin. Based on the results of the disk diffusion testing, 33 of 38 isolates showed resistance to pradofloxacin and 3 were intermediate, whereas, by pradofloxacin MIC testing, 35 isolates were classified as resistant and 1 as intermediate. Single alterations in GyrA and GrlA proteins were observed in the 35 resistant isolates and the 1 intermediate isolate (MIC results). These same 36 isolates were also resistant to the other tested fluoroquinolones. The results of the current study showed that MRSP isolates are usually resistant to all fluoroquinolones, including pradofloxacin. Therefore, in routine susceptibility testing to pradofloxacin by disk diffusion, the results should be carefully interpreted for MRSP isolates, especially those resistant to other fluoroquinolones and, in questionable cases, the pradofloxacin MIC should be determined to confirm the susceptibility testing results.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27449131/