Peer-reviewed veterinary case report
How dopamine and dobutamine raise blood pressure in anesthetized dogs
By Rosati, Monica et al.·Published in American journal of veterinary research·2007·Department of Clinical Studies, Canada·View original on PubMed →
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Original publication title: Response of hypotensive dogs to dopamine hydrochloride and dobutamine hydrochloride during deep isoflurane anesthesia.
- Species:
- dog
Plain-English summary
Ten young dogs undergoing deep anesthesia with isoflurane had low blood pressure and were treated with either dopamine or dobutamine to see which would help improve their heart function and urine output. The study found that a dose of 7 micrograms of dopamine per kilogram of body weight effectively raised their blood pressure and improved heart function, while dobutamine alone did not have the same effect. Dopamine also increased urine output, but dobutamine did not contribute to this improvement. Overall, using dopamine alone was the most effective treatment for these dogs during anesthesia.
People also search for: dog low blood pressure treatment · isoflurane anesthesia effects on dogs · dopamine for dogs under anesthesia
Abstract
OBJECTIVE: To evaluate the dose-related cardiovascular and urine output (UrO) effects of dopamine hydrochloride and dobutamine hydrochloride, administered individually and in combination at various ratios, and identify individual doses that achieve target mean arterial blood pressure (MAP; 70 mm Hg) and cardiac index (CI; 150 mL/kg/min) in dogs during deep isoflurane anesthesia. ANIMALS: 10 young clinically normal dogs. PROCEDURES: Following isoflurane equilibration at a baseline MAP of 50 mm Hg on 3 occasions, dogs randomly received IV administration of dopamine (3, 7, 10, 15, and 20 microg/kg/min), dobutamine (1, 2, 4, 6, and 8 microg/kg/min), and dopamine-dobutamine combinations (3.5:1, 3.5:4, 7:2, 14:1, and 14:4 microg/kg/min) in a crossover study. Selected cardiovascular and UrO effects were determined following 20-minute infusions at each dose. RESULTS: Dopamine caused significant dose-dependent responses and achieved target MAP and CI at 7 microg/kg/min; dobutamine at 2 microg/kg/min significantly affected only CI values. At any dose, dopamine significantly affected UrO, whereas dobutamine did not. Target MAP and CI values were achieved with a dopamine-dobutamine combination at 7:2 microg/kg/min; a dopamine-related dose response for MAP and dopamine- and dobutamine-related dose responses for CI were identified. Changes in UrO were associated with dopamine only. CONCLUSIONS AND CLINICAL RELEVANCE: In isoflurane-anesthetized dogs, a guideline dose for dopamine of 7 microg/kg/min is suggested; dobutamine alone did not improve MAP. Data regarding cardiovascular and UrO effects indicated that the combination of dopamine and dobutamine did not provide greater benefit than use of dopamine alone in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17472447/