Peer-reviewed veterinary case report
Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice.
- Journal:
- Nature neuroscience
- Year:
- 2005
- Authors:
- Schmitt, W B et al.
- Affiliation:
- Department of Experimental Psychology · United Kingdom
- Species:
- rodent
Abstract
Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15723058/