Resveratrol inhibits the formation ofbiofilms by reducing PIA, eDNA release, and ROS production.

Abstract

INTRODUCTION: is a zoonotic pathogen that is difficult to control. Resveratrol (RES) has been shown to have significant antibacterial effects. The present study aimed to investigate the inhibitory effect of RES on the formation ofbiofilms and their molecular mechanism. METHODS: First, the minimum inhibitory concentration and inhibitory action curve of RES againstwere obtained through testing. Second, we found that RES can inhibit biofilm formation by reducing the release of polysaccharide intercellular adhesion (PIA) and extracellular DNA (eDNA) from. RESULTS: RES treatment significantly reduced the production of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADPH) in, indicating that ROS and NADPH are closely related to biofilm formation. CONCLUSION: This study demonstrates that RES inhibits the formation ofbiofilms by reducing PIA, eDNA release, and ROS production, and these results provide new ideas for the clinical application of RES in the treatment ofinfection.