Peer-reviewed veterinary case report
Retinol-binding protein changes in hyperthyroid cats
By van Hoek, I et al.·Published in Journal of veterinary internal medicine·2009·Department of Medicine & Clinical Biology of Small Animals·View original on PubMed →
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Original publication title: Retinol-binding protein in serum and urine of hyperthyroid cats before and after treatment with radioiodine.
- Species:
- cat
Plain-English summary
A group of hyperthyroid cats were tested for a protein in their urine that could indicate kidney problems. After receiving treatment with radioiodine, the levels of this protein in their urine decreased significantly, suggesting that some kidney function improved after the treatment. However, the overall levels of the protein in their blood did not change, indicating that while the kidney issues may have improved, the blood protein levels remained stable. This suggests that monitoring this protein in urine could help vets assess kidney health in hyperthyroid cats.
People also search for: hyperthyroid cat treatment · cat kidney problems symptoms · radioiodine therapy for cats
Abstract
BACKGROUND: Retinol-binding protein (RBP) is suggested as a clinically useful marker of renal function in cats. HYPOTHESIS: Serum and urinary RBP concentrations in hyperthyroid (HT) cats differ from those in healthy (H) cats; radioiodine ((131)I) treatment influences serum and urinary RBP concentrations in HT cats. ANIMALS: Ten HT and 8 H cats. METHODS: RBP concentration was evaluated in feline serum and urine samples from a prospective study. RESULTS: There was a significant (P= .003) difference in the urinary RBP/creatinine (uRBP/c) ratios of H (-) and untreated HT (1.4 + or - 1.5 x 10(-2) microg/mg) cats. Serum total thyroxine concentration (1.8 + or - 1.9 microg/dL, 24 weeks) and uRBP/c (0.6 + or - 1.0 x 10(-2) microg/mg, 24 weeks) decreased significantly (P < .001) in HT cats at all time points after treatment with (131)I, and these variables were significantly correlated with one another (r= 0.42, P= .007). Serum RBP concentrations from HT cats (199 + or - 86 microg/L) did not differ significantly (P= .98) from those of H cats (174 + or - 60) and did not change after treatment with (131)I (182 + or - 124 microg/L, P= .80). CONCLUSION AND CLINICAL IMPORTANCE: The presence of urinary RBP in HT cats is a potential marker of tubular dysfunction that is correlated to thyroid status, although it is independent of circulating RBP concentrations. The decreased uRBP/c combined with the absence of changes in serum RBP after treatment suggests that the suspected tubular dysfunction was partly reversible with treatment of (131)I.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19678890/